MIDPOINTS: SUN=APOLLON=KRONOS=VULCANUS/MARGARET THATCHER

That's using the 64th harmonic.

By major aspect, she had Sun=Apollon.  Good for success but not specifically major rulership.

The jury's still out on the Alzheimers.  By 64H, she had Mercury=Saturn/Uranus.  She had a wide opposition of Mercury and Chiron.  These are both pics I found in the charts of autistics too.